Vesatolimod | TLR7 agonist/antiviral
CAS:
1228585-88-3
Catalog Number:
10-4921
Activity:
TLR7 agonist
Chemical Names:
4-Amino-2-butoxy-8-[[3-(pyrrolidine-1-ylmethyl)phenyl]methyl]-5,7-dihydropteridin-6-one
Alternate Name:
GS-9620
Molecular Weight:
410.52
Molecular Formula:
C22H30N6O2
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $165.00 |
Vesatolimod (1228585-88-3) is a Toll-like receptor 7 (TLR7) agonist (EC50 = 290 nM in a HEK293 cell line reporter assay; IFNα MEC 3 nM, 100 fold selectivity over TNFα activation).1 Displays significant antiviral activity via immune activation against HIV2,3, Hepatitis B4,5, Norovirus6, and enterovirus7.
References/Citations:
- Roethle et al. (2013), Identification and Optimization of Toll-like Receptor 7 (TLR7) Agonists for the Oral treatment of Viral Hepatitis; Med. Chem. 56 7324
- Martinsen et al. (2020), The Use of Toll-like Receptor Agonists in HIV-1 Cure Strategies; Immunol. 11 1112
- Riddler et al. (2021), Vesatolimod, a Toll-like Receptor 7 Agonist, Induces Immune Activation in Virally Suppressed Adults Living With Human Immunodeficiency Virus-1; Infect. Dis. 72 e815
- Agarwal et al. (2018), Safety and efficacy of vesatolimod (GS-9620) in patients with chronic hepatitis B who are not currently on antiviral treatment;Viral Hepat. 25 1331
- Niu et al. (2018), Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV vias a type I interferon-dependent mechanism; Hepatol. 68 922
- Tuipulotu et al. (2018), TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation; Antimicrob. Agents Chemother., 62 e02417
- Zhang et al. (2018), GS-9620 inhibits enterovirus 71 replication mainly through the NF-kappaB and PI3K-AKT signaling pathways; Antiviral Res., 153 39
CAS:
1228585-88-3
Catalog Number:
10-4921
Activity:
TLR7 agonist
Chemical Names:
4-Amino-2-butoxy-8-[[3-(pyrrolidine-1-ylmethyl)phenyl]methyl]-5,7-dihydropteridin-6-one
Alternate Name:
GS-9620
Molecular Weight:
410.52
Molecular Formula:
C22H30N6O2
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Vesatolimod (1228585-88-3) is a Toll-like receptor 7 (TLR7) agonist (EC50 = 290 nM in a HEK293 cell line reporter assay; IFNα MEC 3 nM, 100 fold selectivity over TNFα activation).1 Displays significant antiviral activity via immune activation against HIV2,3, Hepatitis B4,5, Norovirus6, and enterovirus7.
References/Citations:
- Roethle et al. (2013), Identification and Optimization of Toll-like Receptor 7 (TLR7) Agonists for the Oral treatment of Viral Hepatitis; Med. Chem. 56 7324
- Martinsen et al. (2020), The Use of Toll-like Receptor Agonists in HIV-1 Cure Strategies; Immunol. 11 1112
- Riddler et al. (2021), Vesatolimod, a Toll-like Receptor 7 Agonist, Induces Immune Activation in Virally Suppressed Adults Living With Human Immunodeficiency Virus-1; Infect. Dis. 72 e815
- Agarwal et al. (2018), Safety and efficacy of vesatolimod (GS-9620) in patients with chronic hepatitis B who are not currently on antiviral treatment;Viral Hepat. 25 1331
- Niu et al. (2018), Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV vias a type I interferon-dependent mechanism; Hepatol. 68 922
- Tuipulotu et al. (2018), TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation; Antimicrob. Agents Chemother., 62 e02417
- Zhang et al. (2018), GS-9620 inhibits enterovirus 71 replication mainly through the NF-kappaB and PI3K-AKT signaling pathways; Antiviral Res., 153 39
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