Vinpocetine | PDE1 inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 20 mg | $30.00 | ||
| 100 mg | $65.00 |
Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1 Also blocks voltage-gated Na+ channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity.2 It reduces inflammatory IL-1β and TNF-α expression in rat hippocampus.3 Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury.4 Vinpocetine exerts neuroprotective effects by suppressing microglial inflammation.5
References/Citations:
1) Hagiwara et al. (1984), Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle; Biochem. Pharmacol., 33 453
2) Molnar and Erdo (1995), Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons; Eur. J. Pharmacol., 273 303
3) Gomez et al. (2014), The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduced inflammatory IL1β and TNF-α expression in rat hippocampus; J. Neurochem., 130 770
4) Wang et al. (2014), Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury; Neuro. Sci. Lett., 566 247
5) Zhao et al. (2011), TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation; Glia Biol., 7 187
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1 Also blocks voltage-gated Na+ channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity.2 It reduces inflammatory IL-1β and TNF-α expression in rat hippocampus.3 Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury.4 Vinpocetine exerts neuroprotective effects by suppressing microglial inflammation.5
References/Citations:
1) Hagiwara et al. (1984), Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle; Biochem. Pharmacol., 33 453
2) Molnar and Erdo (1995), Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons; Eur. J. Pharmacol., 273 303
3) Gomez et al. (2014), The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduced inflammatory IL1β and TNF-α expression in rat hippocampus; J. Neurochem., 130 770
4) Wang et al. (2014), Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury; Neuro. Sci. Lett., 566 247
5) Zhao et al. (2011), TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation; Glia Biol., 7 187
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