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Vinpocetine | PDE1 inhibitor

Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1 Also blocks voltage-gated Na+ channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity.2 It reduces inflammatory IL-1β and TNF-α expression in rat hippocampus.3 Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury.4 Vinpocetine exerts neuroprotective effects by suppressing microglial inflammation.5

References/Citations

1) Hagiwara et al. (1984), Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle; Biochem. Pharmacol., 33 453
2) Molnar and Erdo (1995), Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons; Eur. J. Pharmacol., 273 303
3) Gomez et al. (2014), The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduced inflammatory IL1β and TNF-α expression in rat hippocampus; J. Neurochem., 130 770
4) Wang et al. (2014), Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury; Neuro. Sci. Lett., 566 247
5) Zhao et al. (2011), TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation; Glia Biol., 7 187

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Vinpocetine | PDE1 inhibitor | CAS 42971-09-5

Catalog#  10-1126-0020

$30.00
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CAS:
42971-09-5
Catalog Number:
10-1126
Activity:
PDE1 inhibitor
Chemical Name:
(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Molecular Weight:
350.45
Molecular Formula:
C22H26N2O2
Solubility:
Soluble in DMSO (up to 5 mg/ml), in ethanol (up to 15 mg/ml) or in DMF (up to 3 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO, Ethanol, or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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