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Product Details

NKY-80 | Adenylate cyclase inhibitor

NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively)1,2. More recently shown to indiscriminantly inhibit AC63 .NKY-80 is an extremely useful tool for probing the involvement of adenylyl cylases in cellular signaling4.

References/Citations
1) Onda et al. (2001), Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem., 276 47785
2) Pierre et al. (2009), Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov., 8 321
3) Brand et al. (2013), Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap., 347 265
4) Oritz-Capisano et al. (2007), Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension, 49 618

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NKY-80 | 299442-43-6 | Structure | Supplier

Catalog#  10-1482

$58.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
299442-43-6
Catalog Number:
10-1482
Activity:
Adenylate cyclase inhibitor
Chemical Name:
2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quainazolinone
Molecular Weight:
229.24
Molecular Formula:
C12H11N3O2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
Gold-colored solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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