NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively)1,2. More recently shown to indiscriminantly inhibit AC63 .NKY-80 is an extremely useful tool for probing the involvement of adenylyl cylases in cellular signaling4.
1) Onda et al. (2001), Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem., 276 47785
2) Pierre et al. (2009), Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov., 8 321
3) Brand et al. (2013), Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap., 347 265
4) Oritz-Capisano et al. (2007), Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension, 49 618