Visomitin | Mitochondria-targeted antioxidant

Visomitin (934826-68-3) is a mitochondria-targeted antioxidant.^1,2 A useful tool for studying mitochondrial oxidative stress involvement in many disease states.^3-6 In clinical trials for the treatment of various eye disorders including dry eye, glaucoma, and ocular inflammation.^7,8

References/Citations:

1. Antonenko et al. (2008), Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: synthesis and in vitro studies; Biochemistry (Mosc)., 73 1273
2. Antonenko et al. (2008), Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke; Biochemistry (Mosc)., 73 1288
3. Skulachev et al. (2013), Cationic antioxidants as a powerful tool against mitochondrial oxidative stress; Biochem. Biophys. Res. Commun., 441 275
4. Silva et al. (2016), Targeting Mitochondria in Cardiovascular Disease; Curr. Pharm. Des., 22 5698
5. Isaev et al. (2016), Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type; Rev. Neurosci., 27 849
6. Tabara et al. (2014), Mitochondria-targeted therapies for acute kidney injury; Expert Rev. Mol. Med., 16 e13
7. Brzheskiy et al. (2015), Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome; Adv. Ther., 32 1263
8. Wei et al. (2019), The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface; Ophthalmol. Ther., 8 63