VU0134992 | Kir4.1 Blocker
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $45.00 | ||
| 25 mg | $160.00 |
VU0134992 (755002-90-5) is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
References/Citations:
- Kharade (2018), Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker VU0134992; Mol. Pharmacol. 94 926
- Lu et al. (2022), Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity; Cell. Mol. Life Sci. 79 296
C20H31BrN2O2
98% by TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
VU0134992 (755002-90-5) is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
References/Citations:
- Kharade (2018), Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker VU0134992; Mol. Pharmacol. 94 926
- Lu et al. (2022), Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity; Cell. Mol. Life Sci. 79 296
Related products
-
Elafibranor | PPARalpha/delta agonist
From $65.00CAS:923978-27-2Catalog Number:10-3901Activity:PPARalpha/delta agonistChemical Name:2-[2,6-Dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acidAlternate Name:GFT505Molecular Weight:384.49Molecular Formula:C22H24O4SSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
ML335 | TREK-1,2 activator
From $55.00CAS:825658-06-8Catalog Number:10-3648Activity:TREK-1,2 activatorChemical Name:N-(2,4-Dichlorobenzyl)-4-(methylsulfonamido)benzamideMolecular Weight:373.25Molecular Formula:C15H14Cl2N2O3SSolubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.Shipping Code:RT -
AZD7762 | Checkpoint kinase 1/2 inhibitor
From $60.00CAS:860352-01-8 (free base)Catalog Number:10-4771Activity:Checkpoint kinase 1/2 inhibitorChemical Name:3-(Carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide hydrochlorideMolecular Weight:398.88Molecular Formula:C17H19FN4O2S • HClSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Yellow or brown solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
