VU0810464 | Kir3 activator
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $95.00 | ||
| 25 mg | $335.00 |
VU0810464 (2126040-21-7) is a potent (Kir3.1/3.2; GIRK1/2 EC50 = 165 nM) activator of G protein-gated inwardly-rectifying potassium channels (Kir3; GIRK).1,2 Displays selectivity for Kir3.1/3.2 versus Kir3.1/3.4 as well as selectivity for neuronal versus cardiac Kir3 channels. VU0810464 reduced stress-induced hyperthermia but not anxiety-related behavior in mice.
References/Citations:
- Wieting et al. (2017), Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators; ACS Chem. Neurosci. 8 1873
- Vo et al. (2019), VU0810464, a non-urea G-protein-gated inwardly rectifying K+ (Kir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir 3 channels and reduces stress-induced hyperthermia in mice; Br. J. Pharmacol. 176 2238
C18H21ClFN3O
>98% by TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
VU0810464 (2126040-21-7) is a potent (Kir3.1/3.2; GIRK1/2 EC50 = 165 nM) activator of G protein-gated inwardly-rectifying potassium channels (Kir3; GIRK).1,2 Displays selectivity for Kir3.1/3.2 versus Kir3.1/3.4 as well as selectivity for neuronal versus cardiac Kir3 channels. VU0810464 reduced stress-induced hyperthermia but not anxiety-related behavior in mice.
References/Citations:
- Wieting et al. (2017), Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators; ACS Chem. Neurosci. 8 1873
- Vo et al. (2019), VU0810464, a non-urea G-protein-gated inwardly rectifying K+ (Kir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir 3 channels and reduces stress-induced hyperthermia in mice; Br. J. Pharmacol. 176 2238
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