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Product Details

VX-702 | P38alpha MAP kinase inhibitor

VX-702 (745833-23-2) is a  potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively).1 Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood.1 Inhibits p38 in platelets stimulated by thrombin, collagen, or thromboxane agonist U-46619 at 1 μM.2 Provides only modest clinical efficacy in rheumatoid arthritis.3,4 Delays platelet lesions and leads to better maintenance of stored platelets.5


1) Goldstein et al. (2010), Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders; J. Med. Chem., 53 2345
2) Kuliopulos et al. (2004), Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation; Thromb. Haemostasis, 92 1387
3) Damianov et al. (2009), Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies; Arthrit. Rheumat., 60 1232
4) Ding et al. (2006), Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome; Curr. Opin. Investig. Drugs, 7 1020
5) Scripchenko et al. (2013), An inhibition of p38 mitogen activated protein kinase delays the platelet storage lesion; PLoS One, 8(8)e 70732

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Catalog#  10-2181-0010

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Catalog Number:
p38alpha MAP kinase inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
Physical Properties:
White solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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