size : | Price | Quantity | |
---|---|---|---|
10 mg | $70.00 | ||
50 mg | $280.00 |
WIN-55212-2 mesylate (131543-23-2) is a high affinity cannabinoid receptor agonist (Ki = 62.3 nM for recombinant human CB1 and 3.3 nM for recombinant human CB2)1 with analgesic2 and anti-inflammatory activities. WIN-55212-2 mesylate activates p42 and p44 MAP kinase via cannabinoid receptor-mediated receptor signaling.3
References/Citations:
1) Felder et al. (1995), Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2receptors; Mol. Pharmacol., 48 443
2) Herzberg et al. (1997), The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist in a rat model of neuropathic pain; Neurosci. Lett., 221 157
3) Bouaboula et al. (1995), Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1; Biochem. J., 312 637
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WIN-55212-2 mesylate (131543-23-2) is a high affinity cannabinoid receptor agonist (Ki = 62.3 nM for recombinant human CB1 and 3.3 nM for recombinant human CB2)1 with analgesic2 and anti-inflammatory activities. WIN-55212-2 mesylate activates p42 and p44 MAP kinase via cannabinoid receptor-mediated receptor signaling.3
References/Citations:
1) Felder et al. (1995), Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2receptors; Mol. Pharmacol., 48 443
2) Herzberg et al. (1997), The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist in a rat model of neuropathic pain; Neurosci. Lett., 221 157
3) Bouaboula et al. (1995), Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1; Biochem. J., 312 637
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