WIN-55212-2 mesylate | Cannabinoid CB1/CB2 agonist

CAS:
131543-23-2
Catalog Number:
10-2002
Activity:
Cannabinoid CB1/CB2 agonist
Chemical Name:
(R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate
Molecular Weight:
522.62
Molecular Formula:
C27H26N2O3 CH3SO3H
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
10 mg$70.00
50 mg$280.00

WIN-55212-2 mesylate (131543-23-2) is a high affinity cannabinoid receptor agonist (Ki = 62.3 nM for recombinant human CB1 and 3.3 nM for recombinant human CB2)1 with analgesic2 and anti-inflammatory activities. WIN-55212-2 mesylate activates p42 and p44 MAP kinase via cannabinoid receptor-mediated receptor signaling.3

References/Citations:

1) Felder et al. (1995), Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2receptors; Mol. Pharmacol., 48 443
2) Herzberg et al. (1997), The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist in a rat model of neuropathic pain; Neurosci. Lett., 221 157
3) Bouaboula et al. (1995), Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1; Biochem. J., 312 637

CAS:
131543-23-2
Catalog Number:
10-2002
Activity:
Cannabinoid CB1/CB2 agonist
Chemical Name:
(R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate
Molecular Weight:
522.62
Molecular Formula:
C27H26N2O3 CH3SO3H
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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