WIN-55212-2 mesylate | Cannabinoid CB1/CB2 agonist
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $70.00 | ||
| 50 mg | $280.00 |
WIN-55212-2 mesylate (131543-23-2) is a high affinity cannabinoid receptor agonist (Ki = 62.3 nM for recombinant human CB1 and 3.3 nM for recombinant human CB2)1 with analgesic2 and anti-inflammatory activities. WIN-55212-2 mesylate activates p42 and p44 MAP kinase via cannabinoid receptor-mediated receptor signaling.3
References/Citations:
1) Felder et al. (1995), Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2receptors; Mol. Pharmacol., 48 443
2) Herzberg et al. (1997), The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist in a rat model of neuropathic pain; Neurosci. Lett., 221 157
3) Bouaboula et al. (1995), Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1; Biochem. J., 312 637
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
WIN-55212-2 mesylate (131543-23-2) is a high affinity cannabinoid receptor agonist (Ki = 62.3 nM for recombinant human CB1 and 3.3 nM for recombinant human CB2)1 with analgesic2 and anti-inflammatory activities. WIN-55212-2 mesylate activates p42 and p44 MAP kinase via cannabinoid receptor-mediated receptor signaling.3
References/Citations:
1) Felder et al. (1995), Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2receptors; Mol. Pharmacol., 48 443
2) Herzberg et al. (1997), The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist in a rat model of neuropathic pain; Neurosci. Lett., 221 157
3) Bouaboula et al. (1995), Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1; Biochem. J., 312 637
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