Withaferin A | NFkB and angiogenesis inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $65.00 | ||
| 5 mg | $200.00 |
Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro (IC50 = 12 nM) and in vivo.1 Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2 Covalently binds to the intermediate filament protein, vimentin3 inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in in vivo models.5
References/Citations:
1) Mohan et al. (2004), Withaferin A is a potent inhibitor of angiogenesis; Angiogenesis, 7 115
2) Kaileh et al. (2007), Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with inhibition of its kinase activity; J. Biol. Chem., 282 4253
3) Bargagna-Mohan et al. (2007), The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin; Chem. Biol., 14 623
4) Thaiparambil et al. (2011), Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation; Int. J. Cancer, 129 2744
5) Livne-Bar et al. (2016), Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis; Cell Death Dis., 7 e2386
NMR (Conforms)
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Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro (IC50 = 12 nM) and in vivo.1 Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2 Covalently binds to the intermediate filament protein, vimentin3 inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in in vivo models.5
References/Citations:
1) Mohan et al. (2004), Withaferin A is a potent inhibitor of angiogenesis; Angiogenesis, 7 115
2) Kaileh et al. (2007), Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with inhibition of its kinase activity; J. Biol. Chem., 282 4253
3) Bargagna-Mohan et al. (2007), The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin; Chem. Biol., 14 623
4) Thaiparambil et al. (2011), Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation; Int. J. Cancer, 129 2744
5) Livne-Bar et al. (2016), Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis; Cell Death Dis., 7 e2386
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