WM-1119 | HAT KAT6A inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $60.00 | ||
| 25mg | $195.00 |
WM-1119 (2055397-28-7) is a potent and selective inhibitor of the MYST family histone acetyltransferase (HAT) KAT6A (MOZ) – IC50 = 6.3 nM.1,2 Induces cell cycle exit and cellular senescence without causing DNA damage. WM-1119 repressed the cell proliferation of sorafenib-resistant hepatocellular carcinoma cells.3
References/Citations:
- Baell et al. (2018), Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth; Nature, 560 253
- Priebbenow et al. (2020), Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents; J. Med. Chem., 63 4655
- Jin et al. (2021), KAT6A is associated with sorafenib resistance and contributes to progression of hepatocellular carcinoma by targeting YAP; Biochem. Biophys. Res. Commun., 585 185
C18H13F2N3O3S
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
WM-1119 (2055397-28-7) is a potent and selective inhibitor of the MYST family histone acetyltransferase (HAT) KAT6A (MOZ) – IC50 = 6.3 nM.1,2 Induces cell cycle exit and cellular senescence without causing DNA damage. WM-1119 repressed the cell proliferation of sorafenib-resistant hepatocellular carcinoma cells.3
References/Citations:
- Baell et al. (2018), Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth; Nature, 560 253
- Priebbenow et al. (2020), Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents; J. Med. Chem., 63 4655
- Jin et al. (2021), KAT6A is associated with sorafenib resistance and contributes to progression of hepatocellular carcinoma by targeting YAP; Biochem. Biophys. Res. Commun., 585 185
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