WP631 | SP-1 activated transcription inhibitor
Not available
4-Methylbenzyl-N-bis[daunomycin], mesylate salt
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 500 µg | $270.00 | ||
| 100 µg | $65.00 |
WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human ovarian cancer cells.3 Synergizes with epothilone at induction of apoptosis in human ovarian cancer cells.4 Abrogates HIV-1 replication via inhibition of Tat transactivation.5
References:
- Martin et al. (1999), Bisanthracycline WP631 inhibits basal and Sp-1-activated transcription initiation in vitro; Nucleic Acids Res,, 27 3402
- Mansilla et al. (2004), Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes; Biochemistry, 43 7584
- Gajek et al. (2014), Pro-apoptotic activity of new analog of anthracyclines—WP 631 in advanced ovarian cancer cell line; In Vitro, 28 273
- Bukowska et al. (2016), New Potential chemotherapy for ovarian cancer – Combined therapy with WP 631 and epothilone B; Life Sci., 151 86
- Kutsch et al. (2004), Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription; Antimicrob. Agents Chemother., 43 1652
Not available
4-Methylbenzyl-N-bis[daunomycin], mesylate salt
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human ovarian cancer cells.3 Synergizes with epothilone at induction of apoptosis in human ovarian cancer cells.4 Abrogates HIV-1 replication via inhibition of Tat transactivation.5
References:
- Martin et al. (1999), Bisanthracycline WP631 inhibits basal and Sp-1-activated transcription initiation in vitro; Nucleic Acids Res,, 27 3402
- Mansilla et al. (2004), Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes; Biochemistry, 43 7584
- Gajek et al. (2014), Pro-apoptotic activity of new analog of anthracyclines—WP 631 in advanced ovarian cancer cell line; In Vitro, 28 273
- Bukowska et al. (2016), New Potential chemotherapy for ovarian cancer – Combined therapy with WP 631 and epothilone B; Life Sci., 151 86
- Kutsch et al. (2004), Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription; Antimicrob. Agents Chemother., 43 1652
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