WS6 | Stimulates pancreatic ß-cell proliferation
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $75.00 | ||
| 25mg | $280.00 |
WS6 (1421227-53-3) stimulates human β-cell proliferation both in a dispersed islet proliferation assay and in intact human cultures.1 It has been shown to induce both α- and β-cell proliferation.2 May lead to the development of new therapeutics for diabetes.3 Induces adult hippocampal neurogenesis correlating with its antidepressant effect in a rat model of chronic unpredictable mild stress-induced depression.4 Has been used together with TTNPB and azakenpaullone, as a defined chemical cocktail to induce mouse totipotent stem cells.5 Cell permeable.
References/Citations:
- Shen et al. (2013), Small-molecule inducer of ß cell proliferation identified by high throughput screening; J. Am. Chem. Soc., 135 1669
- Boerner et al. (2015), WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability; Endocrinol. J., 62 379
- Shirakawa and Kulkarni (2016), Novel factors modulating human ß-cell proliferation; Diabetes Obes. Metab, 18 Suppl. 1 71
- Zhang et al. (2021), WS6 Induces Adult Hippocampal Neurogenesis in Correlation to its Antidepressant Effect on the Alleviation of Depressive-like Behavior of Rats; Neuroscience 473 119
- Hu et al. (2022), Induction of mouse totipotent stem cells by a defined chemical cocktail; Nature, Online ahead of pub
C29H31F3N6O3
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
WS6 (1421227-53-3) stimulates human β-cell proliferation both in a dispersed islet proliferation assay and in intact human cultures.1 It has been shown to induce both α- and β-cell proliferation.2 May lead to the development of new therapeutics for diabetes.3 Induces adult hippocampal neurogenesis correlating with its antidepressant effect in a rat model of chronic unpredictable mild stress-induced depression.4 Has been used together with TTNPB and azakenpaullone, as a defined chemical cocktail to induce mouse totipotent stem cells.5 Cell permeable.
References/Citations:
- Shen et al. (2013), Small-molecule inducer of ß cell proliferation identified by high throughput screening; J. Am. Chem. Soc., 135 1669
- Boerner et al. (2015), WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability; Endocrinol. J., 62 379
- Shirakawa and Kulkarni (2016), Novel factors modulating human ß-cell proliferation; Diabetes Obes. Metab, 18 Suppl. 1 71
- Zhang et al. (2021), WS6 Induces Adult Hippocampal Neurogenesis in Correlation to its Antidepressant Effect on the Alleviation of Depressive-like Behavior of Rats; Neuroscience 473 119
- Hu et al. (2022), Induction of mouse totipotent stem cells by a defined chemical cocktail; Nature, Online ahead of pub
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