WX-02-23 | Spliceosome/FOXA1 modulator
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $90.00 | ||
| 25 mg | $295.00 |
WX-02-23 (2929223-35-6) is a spliceosome modulator. It binds to the spliceosome factor SF3B1 stabilizing a spliceosome state with enhanced binding to DDX42. WX-02-23 displayed anti-proliferative effects in Panc 05.04 and Panc 04.03 cells.1 WX-02-23 also modulates the pioneer transcription factor FOXA1 via covalent binding to Cysteine 258 in a DNA-dependent manner (EC50 = 2 µM FOXA1; 12 µM FOXA1-FKHD). It alters activity via relaxation of FOXA1s DNA-binding motif changing chromatin accessibility.2
References/CItations:
- Lazear et al. (2023), Proteomic discovery of chemical probes that perturb protein complexes in human cells; Mol. Cell 83 P1725
- Won et al. (2024), Redirecting the pioneering function of FOXA1 with covalent small molecules; Mol. Cell 84 4125
C26H25N3O5
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
WX-02-23 (2929223-35-6) is a spliceosome modulator. It binds to the spliceosome factor SF3B1 stabilizing a spliceosome state with enhanced binding to DDX42. WX-02-23 displayed anti-proliferative effects in Panc 05.04 and Panc 04.03 cells.1 WX-02-23 also modulates the pioneer transcription factor FOXA1 via covalent binding to Cysteine 258 in a DNA-dependent manner (EC50 = 2 µM FOXA1; 12 µM FOXA1-FKHD). It alters activity via relaxation of FOXA1s DNA-binding motif changing chromatin accessibility.2
References/CItations:
- Lazear et al. (2023), Proteomic discovery of chemical probes that perturb protein complexes in human cells; Mol. Cell 83 P1725
- Won et al. (2024), Redirecting the pioneering function of FOXA1 with covalent small molecules; Mol. Cell 84 4125
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