Xanthohumol | VCP inhibitor / Autophagy inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $280.00 |
Xanthohumol (6754-58-1) binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II)1. Impairs prostate cancer cell growth and proliferation2. Cell permeable.
References/Citations:
1) Sasazawa et al. (2012), Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein; ACS Chem. Biol., 7 892
2) Vene et al. (2012), Xanthohumol impairs prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice; Mol. Med., 18 1292
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Xanthohumol (6754-58-1) binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II)1. Impairs prostate cancer cell growth and proliferation2. Cell permeable.
References/Citations:
1) Sasazawa et al. (2012), Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein; ACS Chem. Biol., 7 892
2) Vene et al. (2012), Xanthohumol impairs prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice; Mol. Med., 18 1292
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