XI-011 | p53 activator/MDM4 inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $205.00 |
XI-011 (59474-01-0) activates p53 by inhibiting expression of one of its negative regulators, MDM4 (MDMX).1 It was able to induce apoptosis in MCF-7 breast cancer cells. XI-011 acted synergistically with cisplatin in inducing apoptosis in head and neck cancer cells.2 It also induced apoptosis in several cervical cancer in vitro and in vivo.3 XI-011 displayed efficacy in treating lung fibrosis in an MDM4-dependent manner.4
References/Citations:
- Wang and Yan (2011), A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells; Neoplasia 13 611
- Roh et al. (2014), XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer; Apoptosis 19 1594
- Zhang et al. (2022), A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis; Pharmacol. Res. 177 106128
- Mei et al. (2023), Pharmacological inhibition of MDM4 alleviates pulmonary fibrosis; Theranostics 13 2787
C17H16N2S·HCl
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
XI-011 (59474-01-0) activates p53 by inhibiting expression of one of its negative regulators, MDM4 (MDMX).1 It was able to induce apoptosis in MCF-7 breast cancer cells. XI-011 acted synergistically with cisplatin in inducing apoptosis in head and neck cancer cells.2 It also induced apoptosis in several cervical cancer in vitro and in vivo.3 XI-011 displayed efficacy in treating lung fibrosis in an MDM4-dependent manner.4
References/Citations:
- Wang and Yan (2011), A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells; Neoplasia 13 611
- Roh et al. (2014), XI-011 enhances cisplatin-induced apoptosis by functional restoration of p53 in head and neck cancer; Apoptosis 19 1594
- Zhang et al. (2022), A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis; Pharmacol. Res. 177 106128
- Mei et al. (2023), Pharmacological inhibition of MDM4 alleviates pulmonary fibrosis; Theranostics 13 2787
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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