XMU-MP-1 | Potent and selective MST1/2 kinase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $275.00 |
XMU-MP-1 (2061980-01-4) is a potent, reversible, and selective inhibitor of the HIPPO pathway kinases MST1 and MST2 (IC50s = 71 nM and 38 nM respectively).1 It promoted liver repair/regeneration in mice and attenuated acetaminophen-induced liver injury. In a subarachnoid hemorrhage mouse model, XMU-MP-1 alleviated neurological deficits, brain edema, neuroinflammation, and white matter injury.2 XMU-MP-1 was also cardioprotective in mice with transverse aortic constriction3 and against ischemia/reperfusion injury4.
References/Citations:
- Fan et al. (2016), Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration; Sci. Transl. Med. 8 352ra108
- Qu et al. (2018); MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-kB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice, Behav. Neurol., 2018 6470957
- Triastuti et al. (2019), Pharmacological inhibition of Hippo pathway, with the novel kinase inhibitor XMU-MP-1, protects the heart against adverse effects during pressure overload; Br. J. Pharmacol. 176 3956
- Liu et al. (2022), XMU-MP-1 protects heart from ischemia/reperfusion injury in mice through modulating Mst1/AMPK pathway; Eur. J. Pharmacol. 919 174801
C17H16N6O3S2
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
XMU-MP-1 (2061980-01-4) is a potent, reversible, and selective inhibitor of the HIPPO pathway kinases MST1 and MST2 (IC50s = 71 nM and 38 nM respectively).1 It promoted liver repair/regeneration in mice and attenuated acetaminophen-induced liver injury. In a subarachnoid hemorrhage mouse model, XMU-MP-1 alleviated neurological deficits, brain edema, neuroinflammation, and white matter injury.2 XMU-MP-1 was also cardioprotective in mice with transverse aortic constriction3 and against ischemia/reperfusion injury4.
References/Citations:
- Fan et al. (2016), Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration; Sci. Transl. Med. 8 352ra108
- Qu et al. (2018); MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-kB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice, Behav. Neurol., 2018 6470957
- Triastuti et al. (2019), Pharmacological inhibition of Hippo pathway, with the novel kinase inhibitor XMU-MP-1, protects the heart against adverse effects during pressure overload; Br. J. Pharmacol. 176 3956
- Liu et al. (2022), XMU-MP-1 protects heart from ischemia/reperfusion injury in mice through modulating Mst1/AMPK pathway; Eur. J. Pharmacol. 919 174801
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
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1-855-FOCUS21
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