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Product Details

Y-27632 dihydrochloride | ROCK family kinase inhibitor

Y-27632 dihydrochloride (129830-38-2) is a specific inhibitor of ROCK family kinases.1 Enhances stem cell survival and proliferation in culture.2 Y-27632 dihydrochloride significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers, or differentiation potential.3

1) Ishizaki et al. (2000), Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases; Mol. Pharmacol., 57 976
2) Gauthaman et al. (2010), Effectis pf ROCK Inhibitor Y-27632 on Normal and Varient Human Embryonic Stem Cells (hESCs) In Vitro: Its Benefits in hESC Expansion; Stem Cell Rev., 6 86
3) Li et al. (2008), The ROCK Inhibitor Y-27632 enhances the Survival Rate of Human Embryonic Stem Cells Following Cryopreservation; Stem Cells Dev., 17 1079
4) Morel et al. (2018), Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature Y-27632; Mol. Cell. Proteomics, 17 1750 [Focus Citation]

Focus Biomolecules supplier, chemical structure of Y-27632 dihydrochloride | ROCK family kinase inhibitor | CAS 129830-38-2

Catalog#  10-2301

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Catalog Number:
ROCK family kinase inhibitor
Chemical Name:
(R)-(+)-trans-4-(1-Aminoethyl)-N-(-4-pyridyl)cyclohexanecarboxamide dihydrochloride
Molecular Weight:
Molecular Formula:
C14H21N3O 2HCl
Soluble in DMSO up to 25 mg/ml) or in Methanol (up to 25 mg/ml).
Physical Properties:
White solid
99% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO or methanol may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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