YC-1 | Soluble guanylyl cyclase activator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $210.00 |
YC-1 (170632-47-0) is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of rabbit platelets (IC50 = 14.6 μM).1 Induces human endometrial cancer cell senescence via modulation of HIF1α activity.2 Induces degradation of HIF1α.3 Protects against glutamate-induced neuronal damage4 and β-amyloid-induced toxicity in differentiated PC12 cells5.
References/Citations:
1) Martin et al. (2001), YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components; Proc. Natl. Acad. Sci. USA, 98 12938
2) Kato et al. (2006), Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1; Int. J. Cancer, 118 1144
3) Kim et al. (2006), A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent; Int. J. Oncol., 29 255
4) Tai et al. (2018), Therapeutic window for YC-1 following glutamate-induced neuronal damage and transient focal cerebral ischemia; Mol. Med. Rep., 17 6490
5) Tsai et al. (2013), The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells.; PLoS One, 8(7) e69320
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
YC-1 (170632-47-0) is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of rabbit platelets (IC50 = 14.6 μM).1 Induces human endometrial cancer cell senescence via modulation of HIF1α activity.2 Induces degradation of HIF1α.3 Protects against glutamate-induced neuronal damage4 and β-amyloid-induced toxicity in differentiated PC12 cells5.
References/Citations:
1) Martin et al. (2001), YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components; Proc. Natl. Acad. Sci. USA, 98 12938
2) Kato et al. (2006), Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1; Int. J. Cancer, 118 1144
3) Kim et al. (2006), A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent; Int. J. Oncol., 29 255
4) Tai et al. (2018), Therapeutic window for YC-1 following glutamate-induced neuronal damage and transient focal cerebral ischemia; Mol. Med. Rep., 17 6490
5) Tsai et al. (2013), The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells.; PLoS One, 8(7) e69320
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