YL-365 | GPR34 antagonist
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $295.00 |
YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and has been implicated in several types of cancer.2 YL-365 showed no activity against various other GPCRs as well as a panel of 378 kinases. It alleviated hyperalgesia in a mouse model of neuropathic pain via downregulation of iNOS in M1 microglia without any toxicity.
References/Citations:
- Xia et al. (2023), Cryo-EM structures of human GPR34 enable the identification of selective antagonists; Proc. Natl. Acad. Sci. USA 120 e2308435120
- Schoeneberg et al. (2018), The G protein-coupled receptor GPR34 – the past 20 years of a grownup; Pharmacol. Ther. 189 71
C34H31ClN2O5
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and has been implicated in several types of cancer.2 YL-365 showed no activity against various other GPCRs as well as a panel of 378 kinases. It alleviated hyperalgesia in a mouse model of neuropathic pain via downregulation of iNOS in M1 microglia without any toxicity.
References/Citations:
- Xia et al. (2023), Cryo-EM structures of human GPR34 enable the identification of selective antagonists; Proc. Natl. Acad. Sci. USA 120 e2308435120
- Schoeneberg et al. (2018), The G protein-coupled receptor GPR34 – the past 20 years of a grownup; Pharmacol. Ther. 189 71
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