YM-155 | Survivin inhibitor

CAS:
781661-94-7
Catalog Number:
10-1473
Activity:
Survivin inhibitor
Alternate Names:
Sepantronium bromide
Chemical Name:
1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
Molecular Weight:
443.3
Molecular Formula:
C20H19BrN4O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Tan to yellow solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$58.00
25 mg$220.00

YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1 Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2 Induces DNA damage.3 YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4

References/Citations:

1) Nakahara et al. (2007), YM155, a novel small-molecule surviving suppressant, induces regression of established human hormone-refractory prostate tumor xenografts; Cancer Res. 67 8014
2) Okamoto et al. (2012), Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin; Mol.Cancer Ther. 11 204
3) Glaros et al. (2012), The ‘survivin suppressants’ NSC 80467 and YM 155 induce a DNA damage response; Cancer Chemother. Pharmacol. 70 207
4) Wang et al. (2014), Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma; Apoptosis 19 748

CAS:
781661-94-7
Catalog Number:
10-1473
Activity:
Survivin inhibitor
Alternate Names:
Sepantronium bromide
Chemical Name:
1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
Molecular Weight:
443.3
Molecular Formula:
C20H19BrN4O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Tan to yellow solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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