YM-58483 | CRAC channel blocker
CAS:
223499-30-7
Catalog Number:
10-2935
Activity:
CRAC channel blocker
Chemical Names:
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
Alternate Name:
BTP2
Molecular Weight:
421.32
Molecular Formula:
C15H9F6N5OS
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $310.00 |
YM-58483 (223499-30-7) is a CRAC (calcium release-activated calcium) channel blocker1, a prototypic store-operated calcium channel2. Inhibits antigen-induced histamine release via modulation of mast cell responses.3 Displays potent analgesic actions in various pain models in mice and is orally active.4 Inhibits T cell-mediated immune responses in vivo.5
References/Citations:
- Zitt et al. (2004), Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2; J. Biol. Chem. 279 12427
- Prakriya et al. (2015), Store-Operated Calcium Channels; Physiol. Rev. 95 1383
- Law et al. (2011), Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2; Int. J. Biochem. Cell Biol. 43 1228
- Gao et al. (2013), Potent analgesic effects of a store-operated calcium channel inhibitor; Pain 154 2034
- Ohga et al. (2008), Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune response in vivo; Int. Immunopharmacol. 8 1787
CAS:
223499-30-7
Catalog Number:
10-2935
Activity:
CRAC channel blocker
Chemical Names:
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide
Alternate Name:
BTP2
Molecular Weight:
421.32
Molecular Formula:
C15H9F6N5OS
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
YM-58483 (223499-30-7) is a CRAC (calcium release-activated calcium) channel blocker1, a prototypic store-operated calcium channel2. Inhibits antigen-induced histamine release via modulation of mast cell responses.3 Displays potent analgesic actions in various pain models in mice and is orally active.4 Inhibits T cell-mediated immune responses in vivo.5
References/Citations:
- Zitt et al. (2004), Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2; J. Biol. Chem. 279 12427
- Prakriya et al. (2015), Store-Operated Calcium Channels; Physiol. Rev. 95 1383
- Law et al. (2011), Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2; Int. J. Biochem. Cell Biol. 43 1228
- Gao et al. (2013), Potent analgesic effects of a store-operated calcium channel inhibitor; Pain 154 2034
- Ohga et al. (2008), Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune response in vivo; Int. Immunopharmacol. 8 1787
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