Z-DEVD-FMK | Caspase-3 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $110.00 |
Z-DEVD-FMK (210344-95-9) is a cell-permeable trimethyl ester form of the irreversible caspase-3 inhibitor DEVD-FMK (fluoromethylketone) with IC50 = 130 nM.1,2 Methyl esters confer cell permeability and are hydrolyzed to the active COOH form via intracellular esterases. Inhibits caspase-3-dependent apoptosis and pyroptosis in a variety of cell lines.3,4 Active in vivo.5
References/Citations:
- Nicholson et al. (1995), Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis; Nature, 376 37
- Brockstedt et al. (1998), Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogenous nuclear ribonucleoprotein A1 by caspase 3; J. Biol. Chem., 273 28057
- Wang et al. (2022), Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells; Oxid. Med. Cell. Longev., 2022 8585598
- Jung et al. (2022), Withanolide modulates the potential crosstalk between apoptosis and autophagy in different colorectal cancer cell lines; Eur. J. Pharmacol., 928 175113
- Knoblach et al. (2004), Caspase inhibitor Z-DEVD-FMK attenuates calpain and necrotic cell death in vitro and after traumatic brain injury; J. Cereb. Blood Flow Metab., 24 1119
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Z-DEVD-FMK (210344-95-9) is a cell-permeable trimethyl ester form of the irreversible caspase-3 inhibitor DEVD-FMK (fluoromethylketone) with IC50 = 130 nM.1,2 Methyl esters confer cell permeability and are hydrolyzed to the active COOH form via intracellular esterases. Inhibits caspase-3-dependent apoptosis and pyroptosis in a variety of cell lines.3,4 Active in vivo.5
References/Citations:
- Nicholson et al. (1995), Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis; Nature, 376 37
- Brockstedt et al. (1998), Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogenous nuclear ribonucleoprotein A1 by caspase 3; J. Biol. Chem., 273 28057
- Wang et al. (2022), Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells; Oxid. Med. Cell. Longev., 2022 8585598
- Jung et al. (2022), Withanolide modulates the potential crosstalk between apoptosis and autophagy in different colorectal cancer cell lines; Eur. J. Pharmacol., 928 175113
- Knoblach et al. (2004), Caspase inhibitor Z-DEVD-FMK attenuates calpain and necrotic cell death in vitro and after traumatic brain injury; J. Cereb. Blood Flow Metab., 24 1119
Related products
-
NOTUMib-1 | NOTUM inhibitor, restores Wnt signaling
From $55.00Catalog Number:10-3756Activity:NOTUM inhibitor, restores Wnt signalingChemical Name:N-(Isoquinolin-6-yl)-2-(o-tolyloxy)acetamideMolecular Weight:292.33Molecular Formula:C18H16N2O2Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming).Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20° (des.)Stability:Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
ML335 | TREK-1,2 activator
From $55.00CAS:825658-06-8Catalog Number:10-3648Activity:TREK-1,2 activatorChemical Name:N-(2,4-Dichlorobenzyl)-4-(methylsulfonamido)benzamideMolecular Weight:373.25Molecular Formula:C15H14Cl2N2O3SSolubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.Shipping Code:RT -
Acalabrutinib | Highly selective BTK inhibitor
From $45.00CAS:1420477-60-6Catalog Number:10-4806Alternate Name:ACP-196Activity:Highly selective BTK inhibitorChemical Name:4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamideMolecular Weight:465.52Molecular Formula:C26H23N7O2Solubility:Soluble in DMSO (up to at least 25 mg/ml)Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
20% OFF
For Postdoc
Customers!
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.