Z-DEVD-FMK | Caspase-3 inhibitor
NMR (Conforms)
Z-DEVD-FMK (210344-95-9) is a cell-permeable trimethyl ester form of the irreversible caspase-3 inhibitor DEVD-FMK (fluoromethylketone) with IC50 = 130 nM.1,2 Methyl esters confer cell permeability and are hydrolyzed to the active COOH form via intracellular esterases. Inhibits caspase-3-dependent apoptosis and pyroptosis in a variety of cell lines.3,4 Active in vivo.5
References/Citations:
- Nicholson et al. (1995), Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis; Nature, 376 37
- Brockstedt et al. (1998), Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogenous nuclear ribonucleoprotein A1 by caspase 3; J. Biol. Chem., 273 28057
- Wang et al. (2022), Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells; Oxid. Med. Cell. Longev., 2022 8585598
- Jung et al. (2022), Withanolide modulates the potential crosstalk between apoptosis and autophagy in different colorectal cancer cell lines; Eur. J. Pharmacol., 928 175113
- Knoblach et al. (2004), Caspase inhibitor Z-DEVD-FMK attenuates calpain and necrotic cell death in vitro and after traumatic brain injury; J. Cereb. Blood Flow Metab., 24 1119
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Z-DEVD-FMK (210344-95-9) is a cell-permeable trimethyl ester form of the irreversible caspase-3 inhibitor DEVD-FMK (fluoromethylketone) with IC50 = 130 nM.1,2 Methyl esters confer cell permeability and are hydrolyzed to the active COOH form via intracellular esterases. Inhibits caspase-3-dependent apoptosis and pyroptosis in a variety of cell lines.3,4 Active in vivo.5
References/Citations:
- Nicholson et al. (1995), Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis; Nature, 376 37
- Brockstedt et al. (1998), Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogenous nuclear ribonucleoprotein A1 by caspase 3; J. Biol. Chem., 273 28057
- Wang et al. (2022), Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells; Oxid. Med. Cell. Longev., 2022 8585598
- Jung et al. (2022), Withanolide modulates the potential crosstalk between apoptosis and autophagy in different colorectal cancer cell lines; Eur. J. Pharmacol., 928 175113
- Knoblach et al. (2004), Caspase inhibitor Z-DEVD-FMK attenuates calpain and necrotic cell death in vitro and after traumatic brain injury; J. Cereb. Blood Flow Metab., 24 1119
Related products
-
Norfluoxetine HCl | Fluoxetine Metabolite
From $60.00CAS:57226-68-3Catalog Number:10-2671Alternate Name:DesmethylfluoxetineActivity:Fluoxetine metaboliteChemical Name:3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride (racemic)Molecular Weight:331.76Molecular Formula:C16H16F3NO HClSolubility:Soluble in DMSO ( up to at least 25 mg/ml)Physical Properties:Beige waxy solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
PNU 74654 | Wnt pathway blocker
From $55.00CAS:113906-27-7Catalog Number:10-4519Activity:Wnt pathway blockerChemical Name:2-Phenoxybenzoic acid [(5-methyl-2-furanyl)methylene]hydrazideMolecular Weight:320.35Molecular Formula:C19H16N2O3Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Off-white solidPurity:>98% by TLC
NMR (conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
HPI-1 | Hedgehog pathway inhibitor
From $75.00CAS:599150-20-6 (anhydrous)Catalog Number:10-4522Activity:Hedgehog pathway inhibitorChemical Name:2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylateMolecular Weight:463.52 (anhydrous)Molecular Formula:C27H29NO6 xH20Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLC
NMR (conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.