Z-Leu-Leu-Leu-vinylsulfone | Proteasome inhibitor

CAS:
 193482-47-2
Catalog Number:
 10-4990
10-4990 ZLeuLeuLeuVS chemical structure

Available Options

SizePriceQuantity 
200 µg$175.00
1 mg$695.00
This product is also available in the following library:

Z-Leu-Leu-Leu-vinylsulfone (193482-47-2) blocks the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptidase activity in isolated proteasomes and in living cells via covalent modification of active site threonine residues.1,2

References/Citations:

  1. Bogyo et al. (1997), Covalent modification of the active site threonine of proteasomal ß subunits and the Escherichia coli homolog HsIV by a new class of inhibitors; Proc. Natl. Acad. Sci. USA 94 6629
  2. Powers et al. (2002); Irreversible inhibitors of serine, cysteine, and threonine proteases, Chem. Rev., 102 4639
CAS:
193482-47-2
Catalog Number:
10-4990
Activity:
Proteasome inhibitor
Chemical Names:
N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-3-methyl-1-[(1E)-2-(methylsulfonyl)ethenyl]butyl]-L-leucinamide
Alternate Name:
ZL3VS; Z-Leu-Leu-Leu-VS
Molecular Weight:
551.74
Molecular Formula:

C28H45N3O6S

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!