Zidovudine | Antiretroviral / Enhances CRISPR repair
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 25 mg | $25.00 | ||
| 100 mg | $90.00 |
Zidovudine (30516-87-1) was the first clinically useful antiretroviral medicine.1,2 Newer antiretroviral medications have replaced it in the clinic. It selectively inhibits reverse transcriptase acting via the triphosphate metabolite. Zidovudine has recently been found to enhance CRISPR-mediated homology-directed repair (HDR) efficiency.3
References/Citations:
1) Yarchoan et al. (1989), Clinical Pharmacology of 3-Azido-2’,3’-Dideoxythymidine (Zidovudine) and Related Dideoxynucleosides; N. Engl. J. Med. 321 726
2) D’Andrea et al. (2008), AZT: an old drug with new perspectives; Curr. Clin. Pharmacol. 3 20
3) Yu et al. (2015), Small molecules enhance CRISPR genome editing in pluripotent stem cells; Cell Stem Cell. 16 142
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Zidovudine (30516-87-1) was the first clinically useful antiretroviral medicine.1,2 Newer antiretroviral medications have replaced it in the clinic. It selectively inhibits reverse transcriptase acting via the triphosphate metabolite. Zidovudine has recently been found to enhance CRISPR-mediated homology-directed repair (HDR) efficiency.3
References/Citations:
1) Yarchoan et al. (1989), Clinical Pharmacology of 3-Azido-2’,3’-Dideoxythymidine (Zidovudine) and Related Dideoxynucleosides; N. Engl. J. Med. 321 726
2) D’Andrea et al. (2008), AZT: an old drug with new perspectives; Curr. Clin. Pharmacol. 3 20
3) Yu et al. (2015), Small molecules enhance CRISPR genome editing in pluripotent stem cells; Cell Stem Cell. 16 142
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