Zoledronic acid | Inhibitor of bone resorption
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $45.00 | ||
| 25 mg | $125.00 |
Zoledronic acid (118072-93-8) is a potent inhibitor of bone resorption (IC50 = 2 nM in mouse calvarial cultures).1 The mechanism of its action is thought to be via inhibition of osteoclastic activity, induction of osteoclast apoptosis and blockage of osteoclastic resorption of mineralized bone and cartilage through its binding to bone. Zoledronic acid is a clinically useful drug for treatment of osteoporosis2, hypercalcemia of malignancy(HCM), multiple myeloma and bone metastases from solid tumors3. It has also been investigated as an antitumor agent and showing efficacy as an adjuvant therapy in several cancers.4,5
References/Citations:
1) Green et al. (1994), Preclinical pharmacology of CGP 42446, a new, potent, heterocyclic bisphosphonate compound; J. Bone Miner. Res., 9 745
2) Deeks and Perry (2008) Zoledronic acid: a review of its use in the treatment of osteoporosis; Drugs Aging, 25 963
3) Perry and Figgitt (2004), Zoledronic acid: a review of its use in patients with advanced cancer; Drugs, 64 1197
4) Koto et al. (2010) Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis and shows combined effects with other anticancer agents; Oncol. Rep., 24 233
5) Tonyali et al. (2010) The role of zoledronic acid in the adjuvant treatment of breast cancer: current perspectives; Expert Opin. Pharmacother., 11 2715
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Zoledronic acid (118072-93-8) is a potent inhibitor of bone resorption (IC50 = 2 nM in mouse calvarial cultures).1 The mechanism of its action is thought to be via inhibition of osteoclastic activity, induction of osteoclast apoptosis and blockage of osteoclastic resorption of mineralized bone and cartilage through its binding to bone. Zoledronic acid is a clinically useful drug for treatment of osteoporosis2, hypercalcemia of malignancy(HCM), multiple myeloma and bone metastases from solid tumors3. It has also been investigated as an antitumor agent and showing efficacy as an adjuvant therapy in several cancers.4,5
References/Citations:
1) Green et al. (1994), Preclinical pharmacology of CGP 42446, a new, potent, heterocyclic bisphosphonate compound; J. Bone Miner. Res., 9 745
2) Deeks and Perry (2008) Zoledronic acid: a review of its use in the treatment of osteoporosis; Drugs Aging, 25 963
3) Perry and Figgitt (2004), Zoledronic acid: a review of its use in patients with advanced cancer; Drugs, 64 1197
4) Koto et al. (2010) Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis and shows combined effects with other anticancer agents; Oncol. Rep., 24 233
5) Tonyali et al. (2010) The role of zoledronic acid in the adjuvant treatment of breast cancer: current perspectives; Expert Opin. Pharmacother., 11 2715
Related products
-
Adapalene | Retinoid RARbeta, gamma agonist
From $30.00CAS:106685-40-9Catalog Number:10-1011Activity:Retinoid RARβ,γ agonistAlternate Names:CD271Chemical Name:6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acidMolecular Weight:412.53Molecular Formula:C28H28O3Solubility:Soluble in DMSO (up to 3 mg/ml) or in DMF (up to 6 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 monthsShipping Code:RT -
Rapamycin | mTOR inhibitor
From $52.00CAS:53123-88-9Catalog Number:10-1104Activity:mTOR inhibitorAlternate Names:SirolimusMolecular Weight:914.17Molecular Formula:C51H79NO13Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 90 mg/ml).Physical Properties:White solidPurity:98%
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
Sunitinib malate | VEGFR, PDGFR kinase inhibitor
From $60.00CAS:341031-54-7Catalog Number:10-1078Activity:VEGFR, PDGFR kinase inhibitorAlternate Names:SU-11248Chemical Name:N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malateMolecular Weight:532.57Molecular Formula:C22H27FN4O4 C4H6O5Solubility:Soluble in DMSO (up to 13 mg/ml).Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
