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1-Aminobenzotriazole | Cytochrome P450 inhibitor

1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2 Blocks omega-oxidation of arachidonic acid but not its epoxidation.3 

References/Citations

1) Mugford et al. (1995), 1-Aminobenzotriazole-Induced Destruction of Hepatic and Renal Cytochrome P450 in Male Sprague-Dawley Rats; Fundam. Appl. Tox., 19 43
2) Emoto et al. (2005), In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: A Comparison With SKF-525A; Drug Metab. Pharmacokinet., 20 351
3) Su et al. (1998), Inhibition of Renal Arachidonic Acid Omega-Hydroxylase Activity With ABT Reduces Blood Pressure in the SHR; Am. J. Physiol., 275 R426

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Focus Biomolecules supplier, chemical structure of 1-Aminobenzotriazole | Cytochrome P450 inhibitor | CAS 1614-12-6

Catalog#  10-2508-0050

$50.00
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CAS:
1614-12-6
Catalog Number:
10-2508
Activity:
Cytochrome P450 inhibitor
Alternate Names:
ABT; 1-Benzotriazolylamine; NSC-114498
Molecular Weight:
134.14
Molecular Formula:
C6H6N4
Solubility:
Soluble in DMSO (up to 30mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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