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1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation

1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays neuroprotective effects in ischemia-induced neuronal cell death3.  Induces embryonic stem cell differentiation into cardiomyocytes and enrichment of pacemaker-like cells.4 Induces production of superoxide and hydrogen peroxide in neutrophils with subsequent apoptosis.5

References/Citations

1) Adeagbo et al. (1999), 1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol., 379 151
2) Orfila et al. (2014), Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci., 40 3179
3) Allen et al. (2011), SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab., 31 2302
4) Muller et al. (2012), Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev., 8 720
5) Fay et al. (2006), SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA, 103 17548

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Catalog#  10-3204-0010

$40.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
10045-45-1
Catalog Number:
10-3204
Activity:
K+ channel activator; Promotes cardiomyocyte differentiation
Chemical Name:
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one
Alternate Names:
1-Ethylbenzimidazolinone
Molecular Weight:
162.19
Molecular Formula:
C9H10N2O
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml)
Physical Properties:
Crystalline solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
Room temperature (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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