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1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation

1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays neuroprotective effects in ischemia-induced neuronal cell death3.  Induces embryonic stem cell differentiation into cardiomyocytes and enrichment of pacemaker-like cells.4 Induces production of superoxide and hydrogen peroxide in neutrophils with subsequent apoptosis.5


1) Adeagbo et al. (1999), 1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol., 379 151
2) Orfila et al. (2014), Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci., 40 3179
3) Allen et al. (2011), SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab., 31 2302
4) Muller et al. (2012), Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev., 8 720
5) Fay et al. (2006), SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA, 103 17548

Focus Biomolecules cell signaling reagent supplier, chemical structure of 1-EBIO | K+ channel activator | CAS 10045-45-1

Catalog#  10-3204-0010

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Catalog Number:
K+ channel activator; Promotes cardiomyocyte differentiation
Chemical Name:
Alternate Names:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml)
Physical Properties:
Crystalline solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
Room temperature (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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