1-O-Acetylbritannilactone | Anti-neuroinflammatory agent

CAS:
 33627-41-7
Catalog Number:
 10-4334
1-O-Acetylbritannilactone chemical structure

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1-O-Acetylbritannilactone (33627-41-7) is a natural product with anti-inflammatory and anti-allergic properties that is extracted from the flowers of Inula japonica and Inula britannica.1,2 It inhibits angiogenesis and lung cancer cell growth via regulation of VEGF signaling.3,4 1-O-acetylbritannilactone suppressed microglial activation by regulating inflammation and autophagy to ameliorate LPS-mediated neuroinflammation via targeting of PDZ binding kinase (PBK).5

References/Citations:

  1. Lu et al. (2012), Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation; J. Ethnopharmacol. 143 151
  2. Liu et al. (2007), Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response; Eur. J. Pharmacol. 577 28
  3. Zhengfu et al. (2015), 1-O-Acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling; Biochem. Biophys. Res. Commun. 464 422
  4. Zhao et al. (2016), Acetylbritannilactone Modulates Vascular Endothelial Growth Factor Signaling and Regulates Angiogenesis in Endothelial Cells; PLoS One 11 e0148968
  5. Zhang et al. (2025), Targeting PBK with small-molecule 1-O-acetyl-4R,6S-britannilactone for the treatment of neuroinflammation; Proc. Natl. Acad. Sci. USA 122 e2502593122
1-O-Acetylbritannilactone, 1-O-Acetylbritannilactone supplier, 33627-41-7, Inulicin, Inulicin supplier, neuroinflammation
CAS:
33627-41-7
Catalog Number:
10-4334
Activity:
Anti-neuroinflammatory agent
Chemical Names:
[(4S)-4-[(3aS,4S,7aR)-4-Hydroxy-6-methyl-3-methylidene-2-oxo-3a,4,7,7a-tetrahydro-1-benzofuran-5-yl]pentyl] acetate
Alternate Name:
Inulicin
Molecular Weight:
308.37
Molecular Formula:

C17H24O5

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

1-O-Acetylbritannilactone (33627-41-7) is a natural product with anti-inflammatory and anti-allergic properties that is extracted from the flowers of Inula japonica and Inula britannica.1,2 It inhibits angiogenesis and lung cancer cell growth via regulation of VEGF signaling.3,4 1-O-acetylbritannilactone suppressed microglial activation by regulating inflammation and autophagy to ameliorate LPS-mediated neuroinflammation via targeting of PDZ binding kinase (PBK).5

References/Citations:

  1. Lu et al. (2012), Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation; J. Ethnopharmacol. 143 151
  2. Liu et al. (2007), Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response; Eur. J. Pharmacol. 577 28
  3. Zhengfu et al. (2015), 1-O-Acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling; Biochem. Biophys. Res. Commun. 464 422
  4. Zhao et al. (2016), Acetylbritannilactone Modulates Vascular Endothelial Growth Factor Signaling and Regulates Angiogenesis in Endothelial Cells; PLoS One 11 e0148968
  5. Zhang et al. (2025), Targeting PBK with small-molecule 1-O-acetyl-4R,6S-britannilactone for the treatment of neuroinflammation; Proc. Natl. Acad. Sci. USA 122 e2502593122

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