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10058-F4 | Myc inhibitor

10058-F4 (403811-55-2) effectively disables c-Myc by inhibiting the c-Myc-Max association and function1. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells2. 10058-F4 induces cell cycle arrest, apoptosis and myeloid differentiation in human acute myeloid leukemia3. Inhibits the MYCN/Max interaction leading to cell cycle arrest, apoptosis and neuronal differentiation in MYCN-amplified neuroblastoma cells4.

References/Citations
1) Yin et al. (2003), Low molecular weight inhibitors of Myc-Max interaction and function; Oncogene, 22 6151
2) Lin et al. (2007), Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells; Anti-Cancer Drugs, 18 161
3) Huang et al. (2006), A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia; Exp. Hematol., 34 1480
4) Zirath et al. (2013), MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells; Proc. Natl. Acad. Sci. USA, 110 10258

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Focus Biomolecules cell signaling reagent supplier, chemical structure of 10058-F4 | Myc inhibitor | CAS 403811-55-2

Catalog#  10-1466

$50.00
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CAS:
403811-55-2
Catalog Number:
10-1466
Activity:
Myc inhibitor
Chemical Name:
5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Molecular Weight:
249.36
Molecular Formula:
C12H11NOS2
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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