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Product Details

ZM-336372 | c-Raf inhibitor

ZM-336372 (208206-29-1) is a potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50μM) with the exception of p38 (SAPK2α) (IC50=2μM) and SAPK2β (p38β) (IC50=2μM). ZM-336372 induces a paradoxical >100-fold activation of c-Raf in whole cells. Induces apoptosis in a variety of cell lines. Cell permeable.

References/Citations
1) Hall-Jackson et al. (1999), Paradoxical activation of Raf by a novel Raf inhibitor; Chem. Biol., 6 559
2) Deming et al. (2010), ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines; J. Surg. Res., 161 28

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Focus Biomolecules cell signaling reagent supplier, chemical structure of ZM-336372 | c-Raf inhibitor | CAS 208206-29-1

Catalog#  10-1030

$80.00
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CAS:
208260-29-1
Catalog Number:
10-1030
Activity:
c-Raf inhibitor
Chemical Name:
3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide
Molecular Weight:
389.46
Molecular Formula:
C23H23N3O3
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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