ZM-336372 (208206-29-1) is a potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50μM) with the exception of p38 (SAPK2α) (IC50=2μM) and SAPK2β (p38β) (IC50=2μM). ZM-336372 induces a paradoxical >100-fold activation of c-Raf in whole cells. Induces apoptosis in a variety of cell lines. Cell permeable.
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