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Product Details

1400W | iNOS inhibitor

1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3 (Ki = 7 nM) over nNOS or eNOS (Ki's of 2 μM and 50 μM respectively).1 1400W is cell permeable and active in vivo.2

1) Garvey et al. (1997), 1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem., 272 4959
2) Thomsen et al. (1997), Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res., 57 3300
3) Pigott et al. (2013), On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol., 168 1255

Focus Biomolecules cell signaling reagent supplier, chemical structure of 1400W | iNOS inhibitor | CAS 214358-33-5

Catalog#  10-4501

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
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Catalog Number:
iNOS inhibitor
Chemical Name:
N-(3-Aminomethyl)benzyl)acetamidine dihydrochloride
Molecular Weight:
Molecular Formula:
C10H15N3 2HCl
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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