17-DMAG | HSP90 inhibitor

CAS:
467214-20-6
Catalog Number:
10-1169
Activity:
HSP90 inhibitor
Alternate Names:
NSC 707545
Chemical Name:
17-[2-(Dimethylamino)ethyl]amino-17-desmethoxygeldanamycin
Molecular Weight:
616.763
Molecular Formula:
C32H48N4O8
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Purple solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
1 mg$35.00
5 mg$100.00

17-DMAG (467214-20-6) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell Permeable.

References/Citations:

1) Glaze et al. (2005), Preclinical toxicity of geldanamycin analog 17-(dimethylaminoethylamino)-demethoxygeldanamycin (17-DMAG) in rats and dogs; potential clinical relevance; Cancer Chemother. Pharmacol., 56 637
2) Kaur et al. (2004), Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator; Clin. Cancer Res., 10 4813

CAS:
467214-20-6
Catalog Number:
10-1169
Activity:
HSP90 inhibitor
Alternate Names:
NSC 707545
Chemical Name:
17-[2-(Dimethylamino)ethyl]amino-17-desmethoxygeldanamycin
Molecular Weight:
616.763
Molecular Formula:
C32H48N4O8
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Purple solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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