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Geldanamycin | HSP90 inhibitor

Geldanamycin (30562-34-6) inhibits HSP90 by binding to its ATP-binding domain (Kd=1.2 μM) and subsequently inhibits HSP90 client proteins. Geldanamycin induces apoptosis in various cell types. Cell permeable.

References/Citations:

1) Neckers et al. (1999), Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity; Invest. New Drugs, 17 361
2) Zang et al. (2006), HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis; Mol. Cell. Biochem., 281 111

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

1 mg, 5 mg

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CAS:
30562-34-6
Catalog Number:
10-1084
Activity:
HSP90 inhibitor
Alternate Names:
NSC 122750; U-29135
Chemical Name:
9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamate
Molecular Weight:
560.65
Molecular Formula:
C29H40N2O9
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Shipping Code:
RT

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Geldanamycin | HSP90 inhibitor

$50.00 – $100.00

CAS:
30562-34-6
Catalog Number:
10-1084
Activity:
HSP90 inhibitor
Alternate Names:
NSC 122750; U-29135
Chemical Name:
9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamate
Molecular Weight:
560.65
Molecular Formula:
C29H40N2O9
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Shipping Code:
RT
  • 1 mg
  • 5 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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