17-GMP-APA-GA | Modified Geldanamycin
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $500.00 | ||
| 1 mg | $140.00 |
17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.
References/Citations:
1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460
2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786
3) Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.
References/Citations:
1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460
2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786
3) Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573
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