17-GMP-APA-GA | Modified Geldanamycin
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $500.00 | ||
| 1 mg | $140.00 |
17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.
References/Citations:
1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460
2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786
3) Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.
References/Citations:
1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460
2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786
3) Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573
Related products
-
BD1047 dihydrobromide | Selective sigma-1 antagonist
From $50.00CAS:138356-21-5Catalog Number:10-4210Activity:Selective sigma-1 antagonistChemical Name:N-[2-(3,4Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromideMolecular Weight:437.04Molecular Formula:C13H20Cl2N2 • 2HBrSolubility:Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT -
Herbimycin A | HSP90 Inhibitor
From $90.00CAS:70563-58-5Catalog Number:10-2567Activity:HSP90 InhibitorChemical Name:(15R)-17-Demethoxy-15 methoxy-11-O-methyl-geldanamycinMolecular Weight:574.68Molecular Formula:C30H42N2O9Solubility:Soluble in DMSO (up to 6 mg/ml).Physical Properties:Yellow lyophilized solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
Geldanamycin | HSP90 inhibitor
From $50.00CAS:30562-34-6Catalog Number:10-1084Activity:HSP90 inhibitorAlternate Names:NSC 122750; U-29135Chemical Name:9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamateMolecular Weight:560.65Molecular Formula:C29H40N2O9Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 monthsShipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
