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2-Bromopalmitic acid | Palmitoylation inhibitor

2-Bromopalmitic acid (18263-25-7) inhibits protein S-palmitoylation.1 Blocks palmitic acid-induced increase in cAMP levels in human primary melanocytes expressing the melanocortin-1 receptor which undergoes an essential palmitoylation as a prerequisite for receptor signaling.2

 

References/Citations

1) Tsukamoto et al. (2013), Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells; PLoS One, 8(9) e75831
2) Chen et al. (2017), Palmitoylation-dependent activation of MC1R prevents melanomagenesis; Nature, 549 399

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Focus Biomolecules reagent supplier, chemical structure of 2-Bromopalmitic acid | Palmitoylation inhibitor | CAS 18263-25-7

Catalog#  10-3284-0500

$40.00
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CAS:
18263-25-7
Catalog Number:
10-3284
Activity:
Palmitoylation inhibitor
Chemical Name:
2-Bromohexadecanoic acid (racemic)
Alternate Names:
2-BP
Molecular Weight:
335.23
Molecular Formula:
C16H31BrO2
Solubility:
Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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