2′-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 20 mg | $50.00 | ||
| 100 mg | $120.00 |
2′-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors.1 Like 5′-Azacytidine (Cat.# 10-1267) and decitabine (Cat.# 10-2412), 2-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation.2 It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways.3 It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo.4
References/Citations:
1) Ren et al. (2011), DNA hypermethylation as a chemotherapy target; Cell Signal, 23 1082
2) Gowher et al. (2004), Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy; Cancer Biol. Ther., 3 1062
3) Zhao et al. (2002), Inhibition of cancer cell proliferation by 5-fluoro-2′-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway; Springerplus, 1 65
4) Kumaki et al. (2001), In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections; Antiviral Res., 92 329
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
2′-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors.1 Like 5′-Azacytidine (Cat.# 10-1267) and decitabine (Cat.# 10-2412), 2-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation.2 It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways.3 It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo.4
References/Citations:
1) Ren et al. (2011), DNA hypermethylation as a chemotherapy target; Cell Signal, 23 1082
2) Gowher et al. (2004), Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy; Cancer Biol. Ther., 3 1062
3) Zhao et al. (2002), Inhibition of cancer cell proliferation by 5-fluoro-2′-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway; Springerplus, 1 65
4) Kumaki et al. (2001), In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections; Antiviral Res., 92 329
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1-855-FOCUS21
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