2′,3′-cGAMP | Endogenous STING agonist

CAS:
1441190-66-4
Catalog Number:
10-1639
Activity:
Endogenous STING agonist
Chemical Name:
Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt
Alternate Name:
2′,3’cyclic GMP-AMP
Molecular Weight:
718.38
Molecular Formula:
C20H22N10O13P2·2Na
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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200 µg$100.00
1 mg$420.00
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2′,3′-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1 Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor.2,3 Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol.4 DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.5

References/Citations:

1) Zhang et al. (2015), Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING; Mol. Cell 51 226
2) Wu et al. (2013), Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA; Science 339 826
3) Sun et al. (2013), Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway; Science 339 786
4) Gui et al. (2019), Autophagy induction via STING trafficking is a primordial function of the cGAS pathway;  Nature, 567 262
5) Li and Chen (2018), The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence and cancer;  J. Exp. Med., 215 1287

CAS:
1441190-66-4
Catalog Number:
10-1639
Activity:
Endogenous STING agonist
Chemical Name:
Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt
Alternate Name:
2′,3’cyclic GMP-AMP
Molecular Weight:
718.38
Molecular Formula:
C20H22N10O13P2·2Na
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

2′,3′-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1 Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor.2,3 Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol.4 DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.5

References/Citations:

1) Zhang et al. (2015), Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING; Mol. Cell 51 226
2) Wu et al. (2013), Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA; Science 339 826
3) Sun et al. (2013), Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway; Science 339 786
4) Gui et al. (2019), Autophagy induction via STING trafficking is a primordial function of the cGAS pathway;  Nature, 567 262
5) Li and Chen (2018), The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence and cancer;  J. Exp. Med., 215 1287

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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