my account
Login
  Loading... Please wait...

Product Details

2GBI | Hv1 channel blocker

2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3  Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4

References/Citations

1) Hong et al. (2015), Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep., 5 14077
2) Hong et al. (2014), Molecular deterinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA, 111 9971
3) Gianti et al. (2016), On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA, 113 E8359
4) Pupo and Gonzalez (2014), In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA, 111 9673

swipe
Focus Biomolecules cell signaling reagent supplier, chemical structure of 2GBI | Hv1 channel blocker | CAS 5418-95-1

Catalog#  10-3127-0050

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
5418-95-1
Catalog Number:
10-3127
Activity:
Hv1 channel blocker
Chemical Name:
2-Guanidinobenzimidazole
Molecular Weight:
175.19
Molecular Formula:
C8H9N5
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming)
Physical Properties:
Beige solid
Purity:
95% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the 2GBI | Hv1 channel blocker to your wish list.