7-Aminoactinomycin D | Fluorescent DNA Probe
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $100.00 | ||
| 5 mg | $400.00 |
7-Aminoactinomycin D (7240-37-1) is a fluorescent, intercalating DNA-binding agent useful for identifying apoptotic cells by flow cytometry. 1,2 Capable of identifying populations representing live, apoptotic, and late apoptotic/dead cells in a quick, simple, reproducible, cost-effective fashion.3,4 Inhibitor of DNA-primed RNA polymerase and DNA polymerase.5
References/Citations:
1) Telieps et al. (2013) Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection, Eur. J. Immunol. 43 1499
2) Schmid et al. (2007) Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D, Nat. Protoc. 2 187
3) Toba et al. (2000) Cell kinetic study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD/PY, Eur.J.Haematol. 64 10
4) Lecoeur et al. (1997) Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods, J. Immunol. Methods 209 111
5) Su et al. (1996) Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect, J. Immunol. 156 4198
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
7-Aminoactinomycin D (7240-37-1) is a fluorescent, intercalating DNA-binding agent useful for identifying apoptotic cells by flow cytometry. 1,2 Capable of identifying populations representing live, apoptotic, and late apoptotic/dead cells in a quick, simple, reproducible, cost-effective fashion.3,4 Inhibitor of DNA-primed RNA polymerase and DNA polymerase.5
References/Citations:
1) Telieps et al. (2013) Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection, Eur. J. Immunol. 43 1499
2) Schmid et al. (2007) Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D, Nat. Protoc. 2 187
3) Toba et al. (2000) Cell kinetic study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD/PY, Eur.J.Haematol. 64 10
4) Lecoeur et al. (1997) Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods, J. Immunol. Methods 209 111
5) Su et al. (1996) Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect, J. Immunol. 156 4198
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