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Product Details

A-803467 | NaV1.8 blocker

A-803467 (944261-79-4) is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and neuropathic pain in a variety of animal models. IC50's for rat and human Nav1.8 are 140 nM and 8.0 nM respectively.

References/Citations
1) Jarvis et al. (2007), A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat; Proc. Natl. Acad. Sci. USA, 104 8520
2) McGaraughty et al. (2008), A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats; J. Pharmacol. Exp. Ther., 324 1204

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Focus Biomolecules cell signaling reagent supplier, chemical structure of A-803467 | NaV1.8 blocker | CAS 944261-79-4

Catalog#  10-1066

$67.00
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CAS:
944261-79-4
Catalog Number:
10-1066
Activity:
NaV1.8 blocker
Chemical Name:
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
Molecular Weight:
357.8
Molecular Formula:
C19H16ClNO4
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).
Physical Properties:
white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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