A1899 | Potent and Selective K2P3.1 blocker

A1899 chemical structure Focus Biomolecules

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5 mg$75.00
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25 mg$245.00
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A1899 (498577-46-1) is a potent and selective blocker of the two-pore domain potassium channels K2P3.1 (TASK-1; IC50 = 7 nM) and K2P9.1 (TASK-3; IC50 = 70 nM).1 It stimulated breathing in isoflurane-anesthetized rats.2

References/Citations:

  1. Streit et al. (2011), A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the the TASK-1 Open Pore; J. Biol. Chem. 286 13977
  2. Choski et al. (2015), Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore; Mol. Pharmacol. 88 926
498577-46-1, A-1899, A1899, A1899 supplier, K2P3.1 blocker, K2P3.1 inhibitor, TASK-1 blocker, TASK-1 inhibitor, two-pore domain potassium channel blocker, two-pore domain potassium channel inhibitor

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A1899 (498577-46-1) is a potent and selective blocker of the two-pore domain potassium channels K2P3.1 (TASK-1; IC50 = 7 nM) and K2P9.1 (TASK-3; IC50 = 70 nM).1 It stimulated breathing in isoflurane-anesthetized rats.2

References/Citations:

  1. Streit et al. (2011), A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the the TASK-1 Open Pore; J. Biol. Chem. 286 13977
  2. Choski et al. (2015), Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore; Mol. Pharmacol. 88 926

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