A1899 | Potent and Selective K2P3.1 blocker
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $245.00 |
A1899 (498577-46-1) is a potent and selective blocker of the two-pore domain potassium channels K2P3.1 (TASK-1; IC50 = 7 nM) and K2P9.1 (TASK-3; IC50 = 70 nM).1 It stimulated breathing in isoflurane-anesthetized rats.2
References/Citations:
- Streit et al. (2011), A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the the TASK-1 Open Pore; J. Biol. Chem. 286 13977
- Choski et al. (2015), Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore; Mol. Pharmacol. 88 926
C30H26F2N2O3
>97% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
A1899 (498577-46-1) is a potent and selective blocker of the two-pore domain potassium channels K2P3.1 (TASK-1; IC50 = 7 nM) and K2P9.1 (TASK-3; IC50 = 70 nM).1 It stimulated breathing in isoflurane-anesthetized rats.2
References/Citations:
- Streit et al. (2011), A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the the TASK-1 Open Pore; J. Biol. Chem. 286 13977
- Choski et al. (2015), Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore; Mol. Pharmacol. 88 926
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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