A77 1726 | DHODH inhibitor

CAS:
108605-62-5
Catalog Number:
10-1436
Activity:
DHODH inhibitor
Alternate Names:
Teriflunomide
Chemical Name:
2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Molecular Weight:
270.21
Molecular Formula:
C12H9F3N2O2
Solubility:
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
A77 1726 Supplier | CAS 108605-62-5 | Focus Biomolecules

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A77 1726 (108605-62-5) is a pyrimidine biosynthesis inhibitor and immunomodulator.1 Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH).2 Leflunomide (Cat.# 10-2369) is rapidly metabolized in human hepatocytes to A77 1726.3 Cell permeable.

References/Citations:

1) Manna et al. (1999), Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression; J. Immunol., 162 2095
2) Davis et al. (1996), immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase; Biochemistry, 35 1270
3) Seah et al. (2008), Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726; Drug Metab. Lett., 2 153

CAS:
108605-62-5
Catalog Number:
10-1436
Activity:
DHODH inhibitor
Alternate Names:
Teriflunomide
Chemical Name:
2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Molecular Weight:
270.21
Molecular Formula:
C12H9F3N2O2
Solubility:
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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