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Leflunomide | Immunosuppressant

Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug).1 Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2; however the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide. Rescues mice from acetaminophen-induced liver injury.3

References/Citations:

1) Teschner et al. (2010), Leflunomide: a drug with a potential beyond rheumatology; Immunotherapy, 2 637
2) Davis et al. (1996), The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase; Biochemistry, 35 1270
3) Latchoumycandane et al. (2007), Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury; Hepatology, 45 412

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

50 mg, 250 mg

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CAS:
75706-12-6
Catalog Number:
10-2369
Activity:
Immunosuppressant
Alternate Names:
RS-34821
Chemical Name:
5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Molecular Weight:
270.21
Molecular Formula:
C12H9F3N2O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Related products

Leflunomide | Immunosuppressant

$40.00 – $160.00

CAS:
75706-12-6
Catalog Number:
10-2369
Activity:
Immunosuppressant
Alternate Names:
RS-34821
Chemical Name:
5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Molecular Weight:
270.21
Molecular Formula:
C12H9F3N2O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
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  • 250 mg
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