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Product Details

AA43279 | Nav1.1 activator

AA43279 (354812-16-1) is a selective Nav1.1activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 μM). In rat hippocampal brain slices it increased the firing activity parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1

References/Citations

1) Frederiksen et al. (2017), A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.; Eur. J. Neuroscience, 46 1887

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Catalog#  10-3503-0005

$60.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
354812-16-1
Catalog Number:
10-3503
Activity:
Nav1.1 activator
Chemical Name:
3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
Molecular Weight:
248.30
Molecular Formula:
C12H12N2O2S
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Tan solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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