ABT-263 | Bcl-2 family inhibitor; Senolytic agent
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $200.00 |
ABT-263 (923564-51-6) is a potent and selective Bcl-2 family inhibitor / BH3 domain mimetic which binds to Bcl-2, Bcl-xL and Bcl-w (Ki<1 nM). A useful tool compound which has shown interesting results in various cancer clinical trials.2 Synergizes with deoxyglucose and other agents, inducing apoptosis in cancer cells in a xenograft mouse model.3 A novel senolytic agent, inducing apoptosis preferentially in senescent cells in a cell type-restricted manner.4
References/Citations:
1) Tse et al. (2008), ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor; Cancer Res., 68 3421
2) Vogler et al. (2009), Bcl-2 inhibitors: small molecules with a big impact on cancer therapy; Cell Death Differ., 16 360
3) Yamaguchi et al. (2011), Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy; PLoS ONE, 6(9) e24102
4) Zhu et al. (2016), Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors; Aging Cell, 15 428
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ABT-263 (923564-51-6) is a potent and selective Bcl-2 family inhibitor / BH3 domain mimetic which binds to Bcl-2, Bcl-xL and Bcl-w (Ki<1 nM). A useful tool compound which has shown interesting results in various cancer clinical trials.2 Synergizes with deoxyglucose and other agents, inducing apoptosis in cancer cells in a xenograft mouse model.3 A novel senolytic agent, inducing apoptosis preferentially in senescent cells in a cell type-restricted manner.4
References/Citations:
1) Tse et al. (2008), ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor; Cancer Res., 68 3421
2) Vogler et al. (2009), Bcl-2 inhibitors: small molecules with a big impact on cancer therapy; Cell Death Differ., 16 360
3) Yamaguchi et al. (2011), Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy; PLoS ONE, 6(9) e24102
4) Zhu et al. (2016), Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors; Aging Cell, 15 428
Related products
-
Brefeldin A | Inhibits intracellular transport
From $38.00CAS:20350-15-6Catalog Number:10-1071Activity:Inhibits intracellular transportAlternate Names:Fermentation product from Penicillium brefeldianumMolecular Weight:280.37Molecular Formula:C16H24O4Solubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
Geldanamycin | HSP90 inhibitor
From $50.00CAS:30562-34-6Catalog Number:10-1084Activity:HSP90 inhibitorAlternate Names:NSC 122750; U-29135Chemical Name:9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamateMolecular Weight:560.65Molecular Formula:C29H40N2O9Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 monthsShipping Code:RT -
ZM-447439 | Aurora B kinase inhibitor
From $52.00CAS:331771-20-1Catalog Number:10-1037Activity:Aurora B kinase inhibitorChemical Name:N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamideMolecular Weight:513.59Molecular Formula:C29H31N5O4Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.