AC1903 | TRPC5 blocker
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $70.00 | ||
| 50 mg | $280.00 |
AC1903 (831234-13-0) is a potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in a rat model of hypertensive proteineuric kidney disease. The use of this selective tool compound provided a mechanistic rationale for targeting TRPC5 channels in progressive chronic kidney diseases and paves the way for the discovery of new therapeutics. Active in vivo.
References/Citations:
1) Zhou et al. (2017), A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models; Science, 358 1332
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AC1903 (831234-13-0) is a potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in a rat model of hypertensive proteineuric kidney disease. The use of this selective tool compound provided a mechanistic rationale for targeting TRPC5 channels in progressive chronic kidney diseases and paves the way for the discovery of new therapeutics. Active in vivo.
References/Citations:
1) Zhou et al. (2017), A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models; Science, 358 1332
Related products
-
A-803467 | NaV1.8 blocker
From $50.00CAS:944261-79-4Catalog Number:10-1066Activity:NaV1.8 blockerChemical Name:5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideMolecular Weight:357.8Molecular Formula:C19H16ClNO4Solubility:Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Niguldipine HCl | L-type Ca channel blocker
From $64.00CAS:119934-51-9Catalog Number:10-1215Activity:L-type Ca channel blockerMolecular Weight:646.18Molecular Formula:C36H39N3O6·HClSolubility:Soluble in DMSO (up to 25 mg/ml) or in Methanol (up to 25 mg/ml).Physical Properties:White solidPurity:98%
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
A-967079 | TRPA1 blocker
From $50.00CAS:1170613-55-4Catalog Number:10-1055Activity:TRPA1 blockerChemical Name:(1E,3E)-1-(4-Fluorophenyl)-2-methylpent-1-en-3-one oximeMolecular Weight:207.25Molecular Formula:C12H14FNOSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 monthsShipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.