AC1903 (831234-13-0) is a potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in a rat model of hypertensive proteineuric kidney disease. The use of this selective tool compound provided a mechanistic rationale for targeting TRPC5 channels in progressive chronic kidney diseases and paves the way for the discovery of new therapeutics. Active in vivo.          

References/Citations

1) Zhou et al. (2017), A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models; Science, 358 1332