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Product Details

Actinonin | Leucyl aminopeptidase inhibitor

Actinonin (13434-13-4) is a potent hydroxamic acid inhibitor of aminopeptidases which displays analgesic effects by inhibiting enkephalin-degrading enzymes.1 Actinonin also inhibits peptide deformylase.2 Induces apoptosis and displays antitumor activity in vivo.3 Inhibits neutrophil collagenase and other MMPs.4 Induces mitochondrial proteotoxicity.5

1) Hachisu et al. (1987), Analgesic effect of actinonin, a new potent inhibitor of multiple encephalin degrading enzymes; Life Sci., 41 235
2) Lee et al. (2004), Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics; J. Clin. Invest., 114 1107
3) Xu et al. (1998), Antitumor activity of actinonin in vitro and in vivo; Clin. Cancer Res., 4 171
4) Sina et al. (2009), Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated pro-MMP-2 activation; Cancer Lett., 279 171
5) Burman et al. (2017) Mitochondrial fission facillitate the selective mitophagy of protein aggregates; J. Cell Biol., 216 3231

Focus Biomolecules supplier, chemical structure of Actinonin | Leucyl aminopeptidase inhibitor | CAS 13434-13-4

Catalog#  10-2549

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Catalog Number:
Leucyl aminopeptidase inhibitor
Chemical Name:
3-[[1-[-2-Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]-octanohydroxamic acid
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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