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Actinonin | Leucyl aminopeptidase inhibitor

Actinonin (13434-13-4) is a potent hydroxamic acid inhibitor of aminopeptidases which displays analgesic effects by inhibiting enkephalin-degrading enzymes.1 Actinonin also inhibits peptide deformylase.2 Induces apoptosis and displays antitumor activity in vivo.3 Inhibits neutrophil collagenase and other MMPs.4 Induces mitochondrial proteotoxicity.5

References/Citations
1) Hachisu et al. (1987), Analgesic effect of actinonin, a new potent inhibitor of multiple encephalin degrading enzymes; Life Sci., 41 235
2) Lee et al. (2004), Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics; J. Clin. Invest., 114 1107
3) Xu et al. (1998), Antitumor activity of actinonin in vitro and in vivo; Clin. Cancer Res., 4 171
4) Sina et al. (2009), Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated pro-MMP-2 activation; Cancer Lett., 279 171
5) Burman et al. (2017) Mitochondrial fission facillitate the selective mitophagy of protein aggregates; J. Cell Biol., 216 3231

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Focus Biomolecules supplier, chemical structure of Actinonin | Leucyl aminopeptidase inhibitor | CAS 13434-13-4

Catalog#  10-2549

$35.00
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CAS:
13434-13-4
Catalog Number:
10-2549
Activity:
Leucyl aminopeptidase inhibitor
Chemical Name:
3-[[1-[-2-Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]-octanohydroxamic acid
Molecular Weight:
385.51
Molecular Formula:
C19H36N3O5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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