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Adapalene | Retinoid RARbeta, gamma agonist

Adapalene (106685-40-9) is a stable analog of retinoic acid that acts as a selective agonist for RARβ and RARγ. Adapalene also inhibits proliferation and induces apoptosis in colorectal cancer cells in culture.

References/Citations
1) Michel et al. (1998), Pharmacology of Adapalene; Br. J. Dermatol., 139 Suppl. 52 3
2) Ocker et al. (2003), The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells on vitro; Int. J. Cancer, 107 453
3) Milikan et al. (2000), Adapalene: an update on newer comparative studies between the various retinoids; Int. J. Dermatol., 39 784
4) Bernard et al. (1993), Adapalene, a new chemical entity with retinoid activity; Skin Pharmacol., 6 61

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Focus Biomolecules cell signaling reagent supplier, structure Adapalene | Retinoid RARβ, RARγ agonist | CAS 106685-40-9

Catalog#  10-1011

$45.00
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CAS:
106685-40-9
Catalog Number:
10-1011
Activity:
Retinoid RARβ,γ agonist
Alternate Names:
CD271
Chemical Name:
6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid
Molecular Weight:
412.53
Molecular Formula:
C28H28O3
Solubility:
Soluble in DMSO (up to 3 mg/ml) or in DMF (up to 6 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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